1) Make your podcast perfect, not otherwise:
Which is to say, make sure your podcast is perfect. A nationally-known host is a perfect example. Start there. If you can get Jimmy Fallon or Larry David to host your podcast, that'd be perfect.
2) Already be an audio recording engineer:
This cannot be emphasized enough. Ideally, you should already have years of knowledge and experience with audio recording, the associated tech, the scientific principles behind it, and a deep understanding of the history and theory behind audio content. Bachelor's Degree in Audio engineering required; Master's preferred.
3) It's all about content:
Many beginners forget: you need content. Thankfully, there's plenty of perfectly good premises that are worth recycling. Ask yourself: "what podcasts do I enjoy listening to?" Then make something similar to, but legally distinct from, that.
4) Don't swear:
Or do. Fuck it. I'm not your dad. Just do it perfect.
5) Audio quality:
This can be neglected almost entirely if your host is popular enough, but if your just some schmuck then you need one Shure SM-7 for each host/guest, tube preamps, a 24-channel mixer, a $3k Mac, a treated room to use the equipment, a new house to hold the room, and an empire to build the house.
6) Drink:
You might think it's "unprofessional" or "wrong" to be drunk while podcasting, but the fact is that being DWP is still legal in all 50 states and Canada. Many of your favorite shows are hosted by notorious drunks that are too red-nosed, bleary-eyed, and cirrotic to appear in visual mediums. Brown liquor is recommended.
7) Editing:
Why bother? There's a 30-second skip button, right? The listeners are already familiar with it, trust me.